Human Interferon gamma protein, His tag (active)

Catalogue Number: GTX00083-PRO-GTX

Manufacturer:	GeneTex
Preservative:	ProClin 300
Physical state:	Lyophilized
Type:	Interferons
Alias:	interferon gamma , IFG , IFI
Host Cell:	E.coli
Shipping Condition:	Blue Ice
Unit(s):	10 ug
Application:	FA

Overview
Datasheets

Description

Description: This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]

Additional Text

Uniprot ID

P01579

Gene Name

IFNG

Gene ID

3458

Accession Number

NP_000610.2

Protein Tag

HIS Tag

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Application Notes

IFN-γ is a dimerized soluble cytokine that is the only member of the type II class of interferons. The importance of IFNγ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. As reported, IFNγ is an important activator of human monocytic THP-1 cells. Therefore, THP-1 cells were incubated in RPMI-1640 with various concentration of IFN-γ, then cells were observed by inverted microscope everyday. After stimulated with IFN-γ (2 ng/ml) for 5 days, morphological changes occurred in THP-1 cells which displayed the shape of fusiform or polygon and were more likely to adhere.

GTX00083-PRO Datasheet

Price

£172.00

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