SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [CR3022-RB]
Catalogue Number: GTX01556-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.02% ProClin 300|0.02% ProClin 300 |
| Physical state: | Liquid |
| Type: | Recombinant Monoclonal |
| Alias: | 2019-nCoV Spike , SARS-CoV-2 Spike , COVID-19 Spike |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | CR3022-RB |
| Isotype: | IgG |
| Immunogen: | The original monoclonal antibody was generated by sequencing peripheral blood lymphocytes of a patient exposed to the SARS-CoV. |
| Application: | ELISA, NT, Inh |
Additional Text
Concentration
1 mg/ml
Uniprot ID
P59594
Purification
Protein A purified
Gene ID
1489668
Gene Name
S
Antibody Clonality
Recombinant Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Short Description
This antibody binds to both SARS-CoV and SARS-CoV-2 with high affinity (PMID: 16796401 & 32065055). The initial characterization of the binding of this antibody was performed by ELISA and indicates potential for the development of diagnostic assays, as both virus-capture assays, or as controls in serological assays measuring immune responses to virus exposure. The original human IgG1 version of the antibody works synergistically in combination with another non-competing SARS antibody CR3014 and is a potential candidate for passive immune prophylaxis of SARS-CoV infection (ter Meulen et al., 2006). The original antibody (human IgG1) was also reported to bind the 2019-nCoV RBD (KD of 6.3 nM). This antibody may have potential as a therapeutic agent, alone or in combination with other neutralizing antibodies for treatment of 2019-nCoV infections (Tian et al., 2020).
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX01556 Datasheet
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