MSH6 antibody [MSVA-906R] HistoMAX™
Catalogue Number: GTX04416-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.05% Sodium azide |
| Molecular Weight: | 153 |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | mutS homolog 6 , GTBP , GTMBP , HNPCC5 , HSAP , p160 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 500 ul |
| Host name: | Rabbit |
| Clone: | MSVA-906R |
| Isotype: | IgG |
| Immunogen: | Recombinant fragment (around aa 1-100) of human MSH6 protein |
| Application: | IHC-P |
Description
Description: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
Additional Text
Gene Name
MSH6
Gene ID
2956
Uniprot ID
P52701
Purification
Protein A/G Purified
Concentration
0.2 mg/ml
Molecular Weight
153
Antibody Clonality
Recombinant Monoclonal
Application Notes
IHC-P: 1:75-1:150. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Short Description
This antibody was validated on 76 different Normal Tissues by IHC-P.Go to Normal Tissue GalleryGo to Cancer Tissue Gallery
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX04416 Datasheet
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