Topoisomerase II alpha antibody [MSVA-802R] HistoMAX™
Catalogue Number: GTX04422-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.05% Sodium azide |
| Molecular Weight: | 174 |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | DNA topoisomerase II alpha , TOP2 , TP2A |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 500 ul |
| Host name: | Rabbit |
| Clone: | MSVA-802R |
| Isotype: | IgG |
| Immunogen: | Recombinant human Topoisomerase II alpha fragment (aa1352-1493) |
| Application: | IHC-P |
Description
Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
Additional Text
Gene Name
TOP2A
Gene ID
7153
Uniprot ID
P11388
Purification
Protein A/G Purified
Concentration
0.2 mg/ml
Molecular Weight
174
Antibody Clonality
Recombinant Monoclonal
Application Notes
IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Short Description
This antibody was validated on 76 different Normal Tissues by IHC-P.Go to Normal Tissue GalleryGo to Cancer Tissue Gallery
Storage Note
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
GTX04422 Datasheet
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