SQSTM1 / P62 antibody [N3C1], Internal

Catalogue Number: GTX100685-GTX

Manufacturer:	GeneTex
Preservative:	0.025% ProClin 300
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	sequestosome 1 , A170 , DMRV , FTDALS3 , NADGP , OSIL , PDB3 , ZIP3 , p60 , p62 , p62B
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 25 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human SQSTM1 / P62. The exact sequence is proprietary.
Application:	FACS, ICC, IF, IHC-P, IP, WB, PLA

Overview
Datasheets

Description

Description: This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq]

Additional Text

Gene Name

SQSTM1

Uniprot ID

Q13501

Gene ID

8878

Concentration

0.39 mg/ml

Purification

Affinity Purified

Molecular Weight

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. FACS: 1:50-1:200. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Short Description

SQSTM1 antibody, also known as ubiquitin-binding protein p62 antibody, detects the SQSTM1 protein that interacts with LC3 proteins to execute autophagosomal degradation. SQSTM1 is also reported to regulate the activation of NFκB1 downstream signaling in addition to having other cellular functions.

GTX100685 Datasheet

GTX100685 Reference

Price

£285.00

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