Von Hippel Lindau antibody

Catalogue Number: GTX101087-GTX

Manufacturer:	GeneTex
Preservative:	0.025% ProClin 300
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	von Hippel-Lindau tumor suppressor , HRCA1 , RCA1 , VHL1 , pVHL
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 25 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Recombinant protein encompassing a sequence within the center region of human Von Hippel Lindau. The exact sequence is proprietary.
Application:	ICC, IF, IHC-P, IP, WB

Overview
Datasheets

Description

Description: Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]

Additional Text

Gene ID

7428

Uniprot ID

P40337

Molecular Weight

Gene Name

VHL

Purification

Affinity Purified

Concentration

1.27 mg/ml

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Application Notes

WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX101087 Datasheet

GTX101087 Reference

Price

£285.00

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