Catalogue Number: GTX10191-GTX
Manufacturer: | GeneTex |
Preservative: | 0.09% Sodium azide |
Physical state: | Liquid |
Type: | Monoclonal Primary Antibody - Unconjugated |
Alias: | pappalysin 1 , ASBABP2 , DIPLA1 , IGFBP-4ase , PAPA , PAPP-A , PAPPA1 |
Shipping Condition: | Blue Ice |
Storage Condition: | 2-8°C |
Unit(s): | 100 ug |
Host name: | Mouse |
Clone: | 5H9 |
Isotype: | IgG2b |
Immunogen: | Purified human PAPP-A/proMBP (heterotetrameric PAPP-A, htPAPP-A) complex. |
Application: | ELISA, IP, WB |
Description: This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
PAPPA
5069
181
Protein A purified
Q13219
Monoclonal
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption