alpha Actinin 4 antibody [N2C1], Internal

Catalogue Number: GTX113115-GTX

Manufacturer:	GeneTex
Preservative:	0.01% Thimerosal
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	actinin alpha 4 , ACTININ-4 , FSGS , FSGS1
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 25 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Recombinant protein encompassing a sequence within the center region of human alpha Actinin 4. The exact sequence is proprietary.
Application:	ICC, IF, IHC-P, WB

Overview
Datasheets

Description

Description: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq]

Additional Text

Gene Name

ACTN4

Uniprot ID

O43707

Gene ID

Concentration

1.03 mg/ml

Purification

Affinity Purified

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Molecular Weight

105

Application Notes

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX113115 Datasheet

GTX113115 Reference

Price

£285.00

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Quantity
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