Histone H2A.XS139ph (phospho Ser139) antibody

Catalogue Number: GTX127342-GTX

Manufacturer:	GeneTex
Preservative:	0.025% ProClin 300
Physical state:	Liquid
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	H2A histone family, member X , zgc:56329
Shipping Condition:	Blue Ice
Unit(s):	100 ul, 25 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Carrier-protein conjugated synthetic peptide surrounding phospho Ser139 of zebrafish Histone H2A.X. The exact sequence is proprietary.
Application:	ICC, IF, IHC-P, WB, IHC-Fr, IHC, IHC-WM

Overview
Datasheets

Description

Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Additional Text

Concentration

0.83 mg/ml

Purification

Affinity Purified

Modification

Phosphorylated, Ser139

Gene ID

394048

Uniprot ID

Q7ZUY3

Gene Name

H2ax

Antibody Clonality

Polyclonal

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption

Molecular Weight

Application Notes

WB: 1:500-1:3000. IHC-P: 1:100-1:2000. IHC-Wm: 1:100-1:500. IHC: 1:100-1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

GTX127342 Datasheet

GTX127342 Reference

Price

£285.00

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Quantity
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