CDKN2A / p14ARF antibody
Catalogue Number: GTX129903-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.025% ProClin 300 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 25 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human CDKN2A / p14ARF. The exact sequence is proprietary. |
| Application: | ICC, IF, IP, WB |
Description
Description: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq]
Additional Text
Gene Name
CDKN2A
Gene ID
1029
Concentration
2.02 mg/mL
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Molecular Weight
17
Application Notes
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Specificity
cyclin-dependent kinase inhibitor 2A Antibody , P16INK4 Antibody , TP16 Antibody , CDKN2 Antibody , MTS1 Antibody , P16 Antibody , P14ARF Antibody , CDKN2A Antibody , CMM2 Antibody , P16INK4A Antibody , MLM Antibody , ARF Antibody , INK4 Antibody , P19ARF Antibody , P19 Antibody , INK4A Antibody , P16-INK4A Antibody , CDK4I Antibody , P14 Antibody , MTS-1 Antibody
GTX129903 Datasheet
SUPPORT
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PRODUCT
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DELIVERY
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