ACE2 antibody
Catalogue Number: GTX15349-GTX
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GTX15349 Image
GTX15349 Image
GTX15349 Image
GTX15349 Image
GTX15349 Image
GTX15349 Image
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IHC-P analysis of human kidney tissue using GTX15349 ACE2 antibody. Working concentration : 2 µg/ml
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ICC/IF analysis of Caco2 cells using GTX15349 ACE2 antibody. Dilution: 5µg/ml Green: ACE2 Blue: DAPI
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WB analysis of mouse stomach tissue lysate using GTX15349 ACE2 antibody. Loading: 15 µg per lane Dilution: 4µg/ml
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WB analysis of rat brain tissue lysate using GTX15349 ACE2 antibody. Loading: 15 µg per lane Dilution: 4µg/ml
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WB analysis of various samples using GTX15349 ACE2 antibody. Loading: 15 µg per lane Dilution: 4µg/ml
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WB analysis of human kidney lysate using GTX15349 ACE2 antibody. Working concentration : 2 µg/ml
GTX15349 Image
IHC-P analysis of human kidney tissue using GTX15349 ACE2 antibody. Working concentration : 2 µg/ml
| Manufacturer: | GeneTex |
| Preservative: | 0.02% Sodium azide |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | angiotensin I converting enzyme 2 , ACEH |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ACE2.The immunogen is located within amino acids 150 - 200 of ACE2. |
| Application: | ELISA, ICC, IF, IHC-P, WB |
Description
Description: Angiotensin converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE1 inhibitors such as catopril and lisinopril do not block ACE2 activity. ACE2 is restricted to the testis, heart, kidney and colon. The full length sequence for ACE2 encodes an 805 amino acid protein with predicted mass of 92.46 kDa and a pI of 5.22. No cross reactivity to ACE1.
Additional Text
Uniprot ID
Q9BYF1
Concentration
1 mg/ml
Gene Name
ACE2
Gene ID
59272
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Molecular Weight
92
Application Notes
WB: 0.5 - 2 µg/mL. IHC-P: 2 µg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
GTX15349 Datasheet
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