Lamin A + C antibody [JoL3]
Catalogue Number: GTX24789-GTX
| Manufacturer: | GeneTex |
| Preservative: | 0.1% Sodium azide |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | lamin A/C , CDCD1 , CDDC , CMD1A , CMT2B1 , EMD2 , FPL , FPLD , FPLD2 , HGPS , IDC , LDP1 , LFP , LGMD1B , LMN1 , LMNC , LMNL1 , MADA , PRO1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 ml |
| Host name: | Mouse |
| Clone: | JoL3 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant bacterially expressed human lamin A |
| Application: | ICC, IF, WB |
Description
Description: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
Additional Text
Gene Name
LMNA
Gene ID
4000
Uniprot ID
P02545
Molecular Weight
74
Purification
Unpurified
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
Recommended Starting Dilutions:For WB: Use at 1/50For ICC/IF: Use at 1:10Optimal dilutions should be determined experimentally by the researcher.
GTX24789 Datasheet
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