LAMP2 antibody
Catalogue Number: GTX30881-GTX
GTX30881 Image
GTX30881 Image
GTX30881 Image
GTX30881 Image
IHC-P analysis of mouse liver tissue using GTX30881 LAMP2 antibody. Dilution : 5 µg/ml
GTX30881 Image
WB analysis of HepG2 cell lysate using GTX30881 LAMP2 antibody. Working concentration : (A) 1 and (B) 2 µg/ml
GTX30881 Image
ICC/IF analysis of HepG2 cells using GTX30881 LAMP2 antibody. Working concentration : 10 µg/ml
| Manufacturer: | GeneTex |
| Preservative: | 0.02% Sodium azide |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | lysosomal associated membrane protein 2 , CD107b , LAMP-2 , LAMPB , LGP-96 , LGP110 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | LAMP-2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human LAMP-2.The immunogen is located within the last 50 amino acids of LAMP-2. |
| Application: | ELISA, ICC, IF, IHC-P, WB |
Description
Description: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components (1,2) and is negatively regulated by TOR (Target of rapamycin) (3). LAMP-2, a highly glycosylated protein associated with the lysosome (4), has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles (5) leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing DanonOs disease is associated with the accumulation of autophagic material in striated myocytes (6). LAMP-2 exists in multiple isoforms (7).
Additional Text
Concentration
1 mg/ml
Gene Name
LAMP2
Gene ID
3920
Uniprot ID
P13473
Purification
Affinity Purified
Molecular Weight
45
Antibody Clonality
Polyclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1 - 2 µg/mL. ICC/IF: 10 µg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
GTX30881 Datasheet
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