CBP antibody [HL2197]
Catalogue Number: GTX638201-GTX
| Manufacturer: | GeneTex |
| Preservative: | No Preservative |
| Physical state: | Liquid |
| Type: | Recombinant Monoclonal |
| Alias: | CREB binding protein , CBP , KAT3A , MKHK1 , RSTS , RSTS1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 25 ul |
| Host name: | Rabbit |
| Clone: | HL2197 |
| Isotype: | IgG |
| Immunogen: | Recombinant fragmemt of human CBP |
| Application: | ICC, IF, IHC-P, WB |
Description
Description: This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
Additional Text
Concentration
1 mg/ml
Gene ID
1387
Gene Name
CREBBP
Uniprot ID
Q92793
Purification
Protein A purified
Antibody Clonality
Recombinant Monoclonal
GTX638201 Datasheet
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