p53 antibody [DO1]
Catalogue Number: GTX70214-GTX
| Manufacturer: | GeneTex |
| Preservative: | No Preservative |
| Physical state: | Liquid |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | tumor protein p53 , BCC7 , BMFS5 , LFS1 , P53 , TRP53 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ul |
| Host name: | Mouse |
| Clone: | DO1 |
| Isotype: | IgG2a |
| Immunogen: | Recombinant human p53 expressed in E. coli. |
| Application: | ELISA, FACS, ICC, IF, IHC-P, IP, WB, IHC-Fr |
Description
Description: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Additional Text
Gene Name
TP53
Gene ID
7157
Uniprot ID
P04637
Concentration
0.25 mg/ml
Molecular Weight
44
Purification
Protein A purified
Antibody Clonality
Monoclonal
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption
Application Notes
WB: 1:500-1:10000. IHC-P: 1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Short Description
p53 antibody recognizes p53 protein, which has a predicted molecular weight of 44 kDa but is typically detected by western blot at 53 kDa. p53, known widely as a tumor suppressor, plays critical roles in various cellular processes including cell cycle regulation, DNA repair, and apoptosis. p53 is mutated in many human cancers.
GTX70214 Datasheet
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