Bulk Anti-Human CD20 (2H7) Antibody

Catalogue Number: ICH1012-ICB

Manufacturer:	IchorBio
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, MS4A1
Shipping Condition:	Blue Ice
Unit(s):	100 mg, 25 mg, 5 mg, 50 mg
Host name:	Mouse
Clone:	2H7
Isotype:	IgG2b, kappa
Immunogen:
Application:	FC, IP, IHC-Fr, MC

Overview
Datasheets

Description

Description: The CD20 antigen, also called MS4A1, B1 and Bp35, is a non-glycosylated, transmembrane spanning, phosphoprotein. The CD20 protein is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells, and is synchronous with the expression of surface IgM. It is also expressed in some follicular dendritic cells and at low levels on a T cell subset. CD20 has been shown to be heavily phosphorylated in activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn), and exists in a complex with MHC class I and II, CD53, CD81, and CD82. Extensive CD20 cross-linking may also influence cell death by apoptosis. Therapy with antibodies against CD20 is a widely used regimen in the treatment of all B cell lymphomas and leukemias.

Additional Text

Gene ID

931

Gene Name

MS4A1

Uniprot ID

P11836

Purification

Protein A/G Purified

Caution

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Concentration

1-5 mg/ml

Antibody Clonality

Monoclonal

Application Notes

Each investigator should determine their own optimal working dilution for specific applications.

Storage Note

anti-CD20 In Vivo Antibody - Low Endotoxin (2H7) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

ICH1012 Datasheet

Price

£2,222.00

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Quantity
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