Bulk anti-Human CD119 antibody (GIR 208)
Catalogue Number: ICH1028-ICB
| Manufacturer: | IchorBio |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Interferon gamma receptor 1, IFN-gamma receptor 1, IFN-gamma-R1, CDw119, Interferon gamma receptor alpha-chain2, IFN-gamma-R-alpha |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 mg, 25 mg, 5 mg, 50 mg |
| Host name: | Mouse |
| Clone: | GIR 208 |
| Isotype: | IgG1 |
| Immunogen: | Human IFN-gamma R alpha, Purified from human placenta |
| Application: | ELISA, FC, IP, WB, NT |
Description
Description: Interferon-gamma (IFN-gamma) exerts its biologic effects by interacting with a single high affinity receptor, IFN-gamma receptor. This receptor is present on almost all cell types except mature erythrocytes. The IFN-gamma receptor consists of two polypeptide chains alpha and beta and requires association of JAK1, JAK2 and Stat1 for IFN-gamma signal transduction. In signal transduction, IFN-gamma induces tyrosine phosphorylation of IFN-gamma receptor alpha (IFNGR1) leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-gamma induced gene transcription. The IFN-gamma receptor is structurally related to the recently cloned IL-10 receptor. GIR 208 binds IFNGR1 and blocks binding of IFN-gamma to the receptor.
Additional Text
Gene ID
3459
Gene Name
IFNGR1
Uniprot ID
P15260
Purification
Protein A/G Purified
Caution
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Concentration
1-5 mg/ml
Antibody Clonality
Monoclonal
Application Notes
Each investigator should determine their own optimal working dilution for specific applications.
Storage Note
anti-CD119 In Vivo Antibody - Low Endotoxin (GIR 208) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
ICH1028 Datasheet
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