Anti-Mouse CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11)
Catalogue Number: ICH1085-ICB
| Manufacturer: | IchorBio |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Ctla4, Cytotoxic T-lymphocyte protein 4, CD152 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 mg, 25 mg, 5 mg, 50 mg |
| Host name: | Armenian Hamster |
| Clone: | UC10-4F10-11 |
| Isotype: | IgG1, kappa |
| Immunogen: | Purified Recombinant Mouse CTLA4 Fc Fusion Protein |
| Application: | FC, IP, WB, FA |
Description
Description: CD152, also known as CTLA-4 or Ly-56 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T (Treg) cells. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.
Additional Text
Purification
Protein A/G Purified
Gene ID
12477
Gene Name
CTLA4
Uniprot ID
P09793
Caution
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Antibody Clonality
Monoclonal
Concentration
≥ 2 mg/ml
Application Notes
Functional Assay: Clone UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding. Each investigator should determine their own optimal working dilution for specific applications.
Storage Note
anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) is stable when stored at 2-8°C. Do not freeze.
ICH1085 Datasheet
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