Anti-PD-1 (RMP1-14)
Catalogue Number: ICH1132-ICB
| Manufacturer: | IchorBio |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Programmed cell death protein 1, Pdcd1, CD279 |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 mg, 25 mg, 5 mg, 50 mg |
| Host name: | Rat |
| Clone: | RMP1-14 |
| Isotype: | IgG2a, kappa |
| Immunogen: | Mouse PD-1 transfected BHK cells |
| Application: | FC, WB, FA, Blk |
Description
Description: CD279, also known as programmed death-1 (PD-1) is a 50-55 kD immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. This RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production.
Additional Text
Gene Name
PDCD1
Purification
Protein A/G Purified
Gene ID
18566
Uniprot ID
Q02242
Caution
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Concentration
1-5 mg/ml
Antibody Clonality
Monoclonal
Application Notes
Blocking: Clone RMP1-14 antibody has been shown to block the binding of both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1. For immune checkpoint antibodies 200 ug per mouse per injection is the standard dosage in the literature. For this anti-PD-1 (clone RMP1-14), we suggest to inject 200 ug/mouse ip generally on days 3, 6 and 9, post injection of tumor. Sometime up to six injections depending on the length of the experiment may be required. Each investigator should determine their own optimal working dilution for specific applications.
Storage Note
anti-PD-1 In Vivo Antibody - Low Endotoxin (RMP1-14) is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -70oC.
ICH1132 Datasheet
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