Bulk Anti-Human CD40 (G28.5) Antibody

Catalogue Number: ICH1156-ICB

Manufacturer:	IchorBio
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	Tumor necrosis factor receptor superfamily member 5, BP50, CD40L receptor
Shipping Condition:	Blue Ice
Unit(s):	100 mg, 25 mg, 5 mg, 50 mg
Host name:	Mouse
Clone:	G28.5
Isotype:	IgG1, kappa
Immunogen:
Application:	FC, FA

Overview
Datasheets

Description

Description: CD40 is a 48 kD type I transmembrane glycoprotein that is a member of the TNFR superfamily. CD40, in association with its ligand CD154 (CD40L) - a 39 kD protein, acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other antigen presenting cells. CD40 is involved in Ig isotype switching and dendritic cell maturation, as well as the activation, differentiation and proliferation of B cells. CD40 interacts with TNFR2 and is involved in the regulation of signal transduction. CD40 is a potential target for cancer immunotherapy. Blocking the interaction of CD40 with its ligand (CD154) is the sought-after therapeutic objective for preventing and/or improving both autoimmune diseases and transplant rejection. Studies have shown that monoclonal antibodies that block CD154 in human clinical trials resulted in unanticipated vascular complications. Hence, an interest in the therapeutic potential for antagonist mAbs specific for human CD40 is emerging. Antibodies of particular therapeutic interest are those that do not inhibit CD40 signaling via physical competition with CD154. Additionally, the interaction of CD40 and its ligand (CD154) is found to be essential for amyloid-beta-induced microglial activation, thus plays a significant part in Alzheimer disease pathogenesis.

Additional Text

Gene Name

CD40

Concentration

1 mg/ml

Purification

Protein A/G Purified

Gene ID

21939

Uniprot ID

P27512

Antibody Clonality

Monoclonal

Application Notes

Each investigator should determine their own optimal working dilution for specific applications.

Storage Note

This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

ICH1156 Datasheet

Price

£2,222.00

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