Bulk Anti-Human Hepsin (3H10.1) Antibody

Catalogue Number: ICH1161-ICB

Manufacturer:	IchorBio
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	Serine protease hepsin, hpn
Shipping Condition:	Blue Ice
Unit(s):	100 mg, 25 mg, 5 mg, 50 mg
Host name:	Mouse
Clone:	3H10.1
Isotype:	IgG1, kappa
Immunogen:	Human hepsin protein
Application:	ELISA, FC

Overview
Datasheets

Description

Description: Hepsin is a type II transmembrane serine protease (TTSP) expressed on the surface of epithelial cells including the liver, kidney, prostate, and thyroid in human tissues. The physiological function of hepsin is unclear, although, In vitro studies have shown that hepsin activates blood clotting factors VII, XII, and IX, pro-urokinase (pro-uPA), and pro-hepatocyte growth factor (pro-HGF). The over-expression of hepsin has been implicated in several types of cancer, especially ovarian and prostate, which makes it an attractive diagnostic marker for cancers. Most notably, hepsin has been identified as one of the most highly induced genes in prostate cancer, and this over-expression is correlated with the cancer progression and metastasis. Furthermore anti-hepsin antibodies have been shown to inhibit the invasion of human prostate cancer cells.1

Additional Text

Gene Name

HPN

Uniprot ID

P05981

Concentration

1 mg/ml

Purification

Protein A/G Purified

Gene ID

3249

Antibody Clonality

Monoclonal

Application Notes

Each investigator should determine their own optimal working dilution for specific applications.

Storage Note

This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

ICH1161 Datasheet

Price

£2,222.00

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