Anti-Mouse CD134 In Vivo Antibody (OX-86) - Low Endotoxin
Catalogue Number: ICH1196-ICB
| Manufacturer: | IchorBio |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | OX-40, TNFRSF4, ACT35 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 mg, 25 mg, 5 mg, 50 mg |
| Host name: | Rat |
| Clone: | OX-86 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | FC, WB, IHC, Act |
Description
Description: CD134 functions as an important immune checkpoint, and its depletion in murine mouse models demonstrate that lack of CD134 expression leads to reduced CD4+ and CD8+ T cells. When CD134 is bound by its corresponding ligand (OX-40L), an optimal T cell response is generated and plays a significant role in determining the amount of memory T-cells remaining after the immune response. CD134 has also been found to play an important role in carcinogenesis, as treatment with activating in vivo antibodies against CD134 enhanced tumor growth, suggesting that CD134 is an important tumor suppressor, and its absence disrupts the immune response to tumors
Additional Text
Purification
Protein A/G Purified
Antibody Clonality
Monoclonal
Application Notes
Each investigator should determine their own optimal working dilution for specific applications.
Concentration
≥ 2 mg/ml
ICH1196 Datasheet
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
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