Mac-1-SAP mouse/human
Catalogue Number: IT-06-ATS
| Manufacturer: | Advanced Targeting Systems |
| Preservative: | No preservative |
| Type: | Targeted Toxin |
| Shipping Condition: | RT |
| Unit(s): | 100 ug, 25 ug, 250 ug |
| Host name: | Rat |
| Clone: | |
| Isotype: | |
| Immunogen: |
Description
Description: This targeted toxin recognizes Mac-1-positive cells in mouse and human. Mac-1-SAP is a chemical conjugate of the rat monoclonal antibody to CD11b (the receptor for C3bi, Cat #AB-N05) and the ribosome-inactivating protein, saporin (Cat. #PR-01). The antibody is from the well-characterized M1/70 clone, and has been created by immunization from mouse macrophages, but reacts well with the human epitope also. It does not recognize the rat form. The immunotoxin is extremely potent, with an ED50 of 5 pM for a mouse monocytic cell line, more than five orders of magnitude more toxic than non-targeted saporin.This product is routinely tested by cytotoxicity assay.
Additional Text
Usage Information
Mac-1-SAP eliminates Mac-1 positive (CD11b positive) cells. All other cells are left untouched.
Antibody Clonality
Monoclonal
Short Description
a tool for eliminating cells that express Mac-1 (CD11b) receptor in mouse or human; targeted via the antibody to CR3 (CD11b), eliminated via saporin
IT-06 Datasheet
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