Human Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein (ITG-HM1A1)
Catalogue Number: ITG-HM1A1-KAT
| Manufacturer: | Kactus |
| Shelf Life: | 12 months |
| Molecular Weight: | The protein has a predicted MW of 129.1 kDa(ITGA1)&83.2 kDa(ITGB1). Due to glycosylation, the protein migrates to 160-200 kDa based on Tris-Bis PAGE result. |
| Physical state: | Lyophilized |
| Type: | Fusion Protein |
| Alias: | Integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB |
| Host Cell: | HEK293 cells |
| Shipping Condition: | RT |
| Unit(s): | 100 ug, 500 ug |
| Application: | WB |
Description
Description: Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen-binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.
Additional Text
Protein Tag
HIS Tag
Short Description
Recombinant Human Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe29-Pro1141(ITGA1) acidic tail & Gln21-Asp728(ITGB1) basic tail.
Storage Note
-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3-6 months after reconstitution.; 2-8°C for 2-7 days after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Uniprot ID
P05556-1, P56199-1
ITG-HM1A1 Datasheet
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