Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein (ITG-HM4V6)
Catalogue Number: ITG-HM4V6-KAT
ITG-HM4V6 Image
ITG-HM4V6 Image
ITG-HM4V6 Image
ITG-HM4V6 Image
The purity of Human ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.
ITG-HM4V6 Image
Human ITGAV&ITGB6 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.
ITG-HM4V6 Image
Immobilized Human ITGAV&ITGB6, His Tag at 2µg/ml (100µl/well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 63.3ng/ml determined by ELISA.
| Manufacturer: | Kactus |
| Shelf Life: | 12 months |
| Molecular Weight: | The protein has a predicted MW of 114 kDa (ITGAV)&79.1 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-150 kDa based on Tris-Bis PAGE result. |
| Physical state: | Lyophilized |
| Type: | Fusion Protein |
| Alias: | Integrin alpha V beta 6; ITGAV&ITGB6 |
| Host Cell: | HEK293 cells |
| Shipping Condition: | RT |
| Unit(s): | 100 ug, 500 ug |
| Application: | ELISA, WB |
Description
Description: ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Additional Text
Protein Tag
HIS-AviTag™
Uniprot ID
P06756-1, P18564-1
Short Description
Recombinant Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe31-Val992(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail.
Storage Note
-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3-6 months after reconstitution.; 2-8°C for 2-7 days after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
ITG-HM4V6 Datasheet
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