Annexin V-AbFluor™ 647 Apoptosis Detection kit (Red Fluorescence)

Catalogue Number: KTA0004-ABK

Manufacturer:	Abbkine
Type:	Apoptosis Detection Kit
Alias:	Annexin 5; Annexin V; AbFluor™ 647
Shipping Condition:	Blue Ice
Unit(s):	100 T, 50 T

Overview
Datasheets

Description

Description: Apoptosis is a form of programmed cell death to remove unwanted, damaged, or senescent cells from tissues. In normal cells, the negative phospholipids reside on the inner side of the cellular membrane while the outer surface of the membrane is occupied by uncharged phospholipids (PS). After a cell has entered apoptosis, the negatively charged PS are transported from the inner to the outer leaflet of the plasma membrane, thus exposing PS to the external cellular environment. The human anticoagulant, Annexin V, is a 35-36 kDa Ca2+-dependent phospholipid-binding protein that has a high affinity for PS. Annexin V labeled with a fluorophore or biotin can identify apoptotic cells by binding to PS exposed on the outer leaflet. Propidium iodide (PI) is a membrane-impermeant DNA-binding dye that is commonly used to selectively stain dead cells in a cell population. PI is excluded by live cells and early apoptotic cells, but stains necrotic and late apoptotic cells with compromised membrane integrity. PI can be excited by the 488, 532, or 546 nm laser lines, and emits red fluorescence.

Additional Text

Short Description

Abbkine Annexin V-AbFluor™ 647 Apoptosis Detection Kit allows the discrimination of intact cells, early apoptotic and late apoptotic or necrotic cells.

KTA0004 Datasheet

Price

£224.00

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