Guanosine-3',5'-bisdiphosphate, (ppGpp)
Catalogue Number: NU-884S-JEN
| Manufacturer: | Jena Bioscience |
| Shelf Life: | 12 months |
| Ph: | 7.5 +/-0 |
| Physical state: | Solution |
| Type: | Nucleosides |
| Shipping Condition: | Blue Ice |
| Storage Condition: | RT |
| Unit(s): | 10 ul |
Description
Description: (p)ppGpp (collective for ppGpp and pppGpp) is a nucleotide based second messenger and a key regulator of stringent stress response in many bacteria[1]. During nutritional starvation (p)ppGpp initiates the switch from bacterial growth into survival mode. Growth is arrested as (p)ppGpp binds RNA polymerase (RNAP) leading to repressed transcription rate of stable RNA (rRNA, tRNA). Instead, transcription of genes involved in biosynthesis of amino acids is enhanced, leading to prolonged survival[2].
Additional Text
Concentration
100-110 mM
Short Description
Guanosine-3',5'-tetraphosphate, Lithium salt
Smile String
[nH]1c(N)nc2n([C@H]3[C@H](O)[C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)O)OP(=O)(O)OP(=O)(O)O)cnc2c1=O
Molecular Weight
603.16 g/mol (free acid)
Molecular Formula
C10H17N5O17P4 (free acid)
Storage Note
store at -20 °C|12 months after date of delivery||Short term exposure (up to 1 week cumulative) to ambient temperature possible.
NU-884S Datasheet
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