Noggin-like Peptide (BMP4,7 Inhibitor)
Catalogue Number: PG-004-PEP
PG-004 image 1
PG-004 Image 2
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PG-004 image 1
NLike Noggin, PG-004 binds to secvetal BMP families and inhibits signals
PG-004 Image 2
We performed a functional comparison test between our Noggin-like Peptide (PG-004) and commercially available recombinant Noggin by measuring smad1 phosphorylation. From the results, our PG-004 showed the inhibitory activity against BMP4 and BMP7 at the same level per molecule compared with recombinant Noggin. We have also confirmed that our Noggin-like Peptide exhibits the inhibitory activity against BMP family proteins with high sequence homology to BMP4 and BMP7. The molecular weight of our Noggin-like Peptide is approximately 2.9 kDa, which is approximately 8 times smaller than the MW of recombinant Noggin.
PG-004 Image 3
We performed a functional comparison test between our Noggin-like Peptide (PG-004) and commercially available recombinant Noggin by measuring smad1 phosphorylation. From the results, our PG-004 showed the inhibitory activity against BMP4 and BMP7 at the same level per molecule compared with recombinant Noggin. We have also confirmed that our Noggin-like Peptide exhibits the inhibitory activity against BMP family proteins with high sequence homology to BMP4 and BMP7. The molecular weight of our Noggin-like Peptide is approximately 2.9 kDa, which is approximately 8 times smaller than the MW of recombinant Noggin.
| Manufacturer: | Peptigrowth |
| Molecular Weight: | 2920.15 (Acetate) |
| Type: | Peptide |
| Shipping Condition: | Dry Ice |
| Unit(s): | 5 ug, 12.5 ug, 62.5 ug, 125 ug |
| Application: | Cell culture |
Description
Description: Fully-Chemically Synthesized Peptide with Antagonistic Activity in Several BMP Families Similar to NogginPeptiGrowth succeeded in developing a synthetic peptide that inhibits a wide range of BMP family proteins and functions like a growth factor, Noggin. Catalog # PG-004, an alternative peptide to Noggin, can be used to maintain undifferentiated state and induce differentiation in manufacturing of regenerative medicine and cell therapy products for pancreas, lung, intestine, etc. Please note that 5 ug of Catalog # PG-004 is equivalent to ~40 ug of recombinant Noggin due to difference in molecular weight.Like growth factor Noggin, Our Noggin-like peptide is a growth factor alternative peptide with antagonistic activity against several BMP families. Our Noggin-like Peptide is expected to be used to maintain undifferentiation and induce differentiation in the development and manufacture of regenerative medicine and cell therapy for pancreas, lung, intestine, etc., which have been actively researched and developed in recent years, and in the preparation of organoids.
Additional Text
PG-004 Biological Activity
Inhibits BMP4 and BMP7 and functions like a growth factor, Noggin
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