VHR, VH1-related phosphatase, human, recombinant, E. coli
Catalogue Number: PR-350-JEN
| Manufacturer: | Jena Bioscience |
| Shelf Life: | 12 months |
| Physical state: | Liquid |
| Type: | Protein Phosphatases |
| Shipping Condition: | Dry Ice |
| Unit(s): | 20 ug |
Description
Description: The mammalian dual-specificity protein-tyrosine phosphatase VHR (for VH1-related) has been identified as a novel regulator of extracellular regulated kinases (ERKs). Vaccinia Virus VH1-related Phosphatase (VHR), also known as Dual-Specificity Phosphatase 3 (DUSP3), removes phosphate groups from tyrosine, serine, and threonine residues. It belongs to a family of phosphatases that selectively dephosphorylate MAP kinases. VHR has been shown to act as a phosphatase for several members of the MAP kinase family including ERK1, ERK2, and JNK. It is a target for the ZAP-70 kinase, and phosphorylation of VHR at tyrosine 138 leads to a downregulation of ERK2 activity. Its welldefined biochemistry has made VHR useful in screening assays for compounds that inhibit phosphatases.
Additional Text
Accession Number
NM_004090
PR-350 MSDS
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