Human IL-12 (IL-12A & IL-12B) protein, His Tag

Catalogue Number: PRP100705-ABK

Manufacturer:	Abbkine
Molecular Weight:	60.2 (24 + 36.2) kDa
Type:	Interleukins
Alias:	CLMF; CLMF2; IL-12A; IL-12B; IL12; IMD28; IMD29; NFSK; NKSF; NKSF1; NKSF2; P35; Interleukin-12 subunit alpha & Interleukin-12 subunit beta; IL12A & IL12B
Shipping Condition:	RT
Unit(s):	20 ug, 5 ug, 50 ug

Overview
Datasheets

Description

Description: IL-12 is composed of a bundle of four α helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-α (TNF-α) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. There also seems to be a link between IL-2 and the signal transduction of IL-12 in NK cells. IL-2 stimulates the expression of two IL-12 receptors, IL-12R-β1 and IL-12R-β2, maintaining the expression of a critical protein involved in IL-12 signaling in NK cells. Enhanced functional response is demonstrated by IFN-γ production and killing of target cells.

Additional Text

Gene ID

3592; 3593

Gene Name

IL12A, IL12B

Accession Number

NP_000873.2,,NP_002178.2

Short Description

Human IL-12 (IL-12A & IL-12B) protein, His Tag, expressed in HEK293 Cells

PRP100705 Datasheet

Price

£433.00

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