Mouse IFN-γ protein, His Tag

Catalogue Number: PRP1015-ABK

Manufacturer:	Abbkine
Molecular Weight:	16.9 kDa
Type:	Interferons
Alias:	IFG; IFI; IFN gamma; Interferon Gamma; Interferon gamma; IFNG
Shipping Condition:	RT
Unit(s):	1 mg, 100 ug, 20 ug, 500 ug

Overview
Datasheets

Description

Description: IFN-γ, also known as IFNG, is a secreted protein which belongs to the type I I interferon family. IFN-γ is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN-γ has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN-γ is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN-γ expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN-γ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.

Additional Text

Gene Name

IFNG

Uniprot ID

P01580

Gene ID

15978

Short Description

Mouse IFN-γ protein, His Tag, expressed in E. coli

PRP1015 Datasheet

Price

£833.00

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