Human CD274/PD-L1 protein, His tag (Animal-Free)

Catalogue Number: PRP2021-ABK

Manufacturer:	Abbkine
Molecular Weight:	26.8 KD
Type:	Fusion Protein
Alias:	Programmed Cell Death 1 Ligand 1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7 homolog 1; B7-H1; CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Shipping Condition:	RT
Unit(s):	1 mg, 10 ug, 100 ug, 50 ug

Overview
Datasheets

Description

Description: Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1 (PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. Plays a critical role in induction and maintenance of immune tolerance to self . As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL-10). The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function (By similarity). The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy.

Additional Text

Gene Name

CD274

Uniprot ID

Q9NZQ7

Gene ID

29126

Short Description

Human CD274/PD-L1 protein, His tag (Animal-Free), expressed in HEK293 Cells

PRP2021 Datasheet

Price

£833.00

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