Human CD86/B7-2 protein, His tag (Animal-Free)
Catalogue Number: PRP2023-ABK
| Manufacturer: | Abbkine |
| Molecular Weight: | 26.2 KD |
| Type: | Other Proteins |
| Alias: | T-lymphocyte activation antigen CD86; Activation B7-2 antigen; CD86 |
| Shipping Condition: | RT |
| Unit(s): | 10 ug, 100 ug, 50 ug |
Description
Description: Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. Recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.
Additional Text
Gene Name
CD86
Uniprot ID
P42081
Gene ID
942
Short Description
Human CD86/B7-2 protein, His tag (Animal-Free), expressed in HEK293 Cells
PRP2023 Datasheet
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