Human CD20 protein, His tag (Animal-Free)
Catalogue Number: PRP2025-ABK
| Manufacturer: | Abbkine |
| Molecular Weight: | 10.6 KD |
| Type: | Other Proteins |
| Alias: | CD80; Activation B7-1 antigen; B7; BB1; CD28LG1; CD28LGB7-1 antigen; T-lymphocyte activation antigen CD80 |
| Shipping Condition: | RT |
| Unit(s): | 1 mg, 10 ug, 100 ug, 50 ug |
Description
Description: B-lymphocyte antigen CD20 is also known as B-lymphocyte surface antigen B1, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1 and MS4A1, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells. It is found on B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells. CD20/MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20/MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Additional Text
Gene ID
931
Gene Name
MS4A1
Uniprot ID
P11836
Short Description
Human CD20 protein, His tag (Animal-Free), expressed in HEK293 Cells
PRP2025 Datasheet
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