Catalogue Number: PRP2028-ABK
Manufacturer: | Abbkine |
Molecular Weight: | 25.4 KD |
Physical state: | Lyophilized |
Type: | Other Proteins |
Alias: | Activation B7-1 antigen|B7|BB1|CD28LG1|CD28LGB7-1 antigen|CD80|T-lymphocyte activation antigen CD80 |
Host Cell: | HEK293 cells |
Shipping Condition: | RT |
Unit(s): | 1 mg, 10 ug, 100 ug, 50 ug |
Description: B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses . Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response . Mature mouse B7-1 consists of a 209 amino acid (aa) extracellular domain (ECD) with two immunoglobulin-like domains, a 22 aa transmembrane segment, and a 38 aa cytoplasmic domain . Within the ECD, mouse B7-1 shares 50% and 68% aa sequence identity with human and rat B7-1, respectively. Alternative splicing generates a short isoform that lacks the second Ig-like domain but retains the ability to bind CD28 . Both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA-4 . B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells.
CD80
941
P33681
HIS Tag
Human CD80/B7-1 protein, His tag (Animal-Free), expressed in HEK293 Cells
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human CD80/B7-1 protein using the buffer we provided not less than 100 µg/mL, which can then be further diluted to other aqueous solutions.