Catalogue Number: PRP2112-ABK
Manufacturer: | Abbkine |
Molecular Weight: | 21.9 KD |
Type: | Interleukins |
Alias: | Interleukin-6; IL-6; B-Cell Hybridoma Growth Factor; Interleukin HP-1; Il6; Il-6 |
Shipping Condition: | Blue Ice |
Unit(s): | 100 ug, 20 ug, 5 ug |
Description: IL-6 is a potent inducer of the acute phase response. Rapid production of IL-6 contributes to host defense during infection and tissue injury, but excessive IL-6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury. In the adaptive immune response, is required for the differentiation of B-cells into immunoglobulin-secreting cells (Probable). Plays a major role in the differentiation of CD4+ T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Together with IL-21, controls the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. Required to drive naive CD4+ T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells. Also required for proliferation of myeloma cells and the survival of plasmablast cells.
IL6
16193
P08505
Mouse IL-6 protein, His tag (Animal-Free), expressed in HEK293 Cells