Mouse IL-6 protein, His tag (Animal-Free)

Catalogue Number: PRP2112-ABK

Manufacturer:	Abbkine
Molecular Weight:	21.9 KD
Physical state:	Lyophilized
Type:	Interleukins
Alias:	B-Cell Hybridoma Growth Factor\|Il6\|IL-6\|Interleukin HP-1\|Interleukin-6
Host Cell:	HEK293 cells
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug, 5 ug

Overview
Datasheets

Description

Description: IL-6 is a potent inducer of the acute phase response. Rapid production of IL-6 contributes to host defense during infection and tissue injury, but excessive IL-6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury. In the adaptive immune response, is required for the differentiation of B-cells into immunoglobulin-secreting cells (Probable). Plays a major role in the differentiation of CD4+ T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Together with IL-21, controls the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. Required to drive naive CD4+ T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells. Also required for proliferation of myeloma cells and the survival of plasmablast cells.

Additional Text

Gene Name

IL6

Gene ID

16193

Uniprot ID

P08505

Protein Tag

HIS Tag

Short Description

Mouse IL-6 protein, His tag (Animal-Free), expressed in HEK293 Cells

Note

Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Mouse IL-6 protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

PRP2112 Datasheet

Price

£316.00

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