Alpha-Synuclein, 96-140
Catalogue Number: S-1014-1-RPE
| Manufacturer: | rPeptide |
| Physical state: | Lyophilized |
| Type: | Other Proteins |
| Shipping Condition: | RT |
| Unit(s): | 0.5 mg |
Description
Description: A deletion mutant of a-synuclein (amino acids 96-140). Additional amino acid(Met) is attached at the N-terminus. Alpha-Synuclein (a-Synuclein) is a 14 kD (140 amino acids) acidic presynaptic protein. It is a major component of Parkinson's disease aggregates and is implicated in the pathogenesis of Parkinson's Disease and related neurodegenerative disorders. a-Synuclein accumulates in the brains of sporadic Parkinson's disease patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of Parkinson's disease. a-Synuclein appears to associate with other proteins that aggregate and is found in a-amyloid plaques and neuritic tangles in Alzheimer's disease.
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