MS4078
Catalogue Number: S0072-SEL
| Manufacturer: | Selleck Chemicals |
| Type: | Other Inhibitors |
| Shipping Condition: | Blue Ice |
| Unit(s): | 25 mg, 5 mg, 10 mM/1 ml, 1 g, 100 mg |
Description
Description: MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALKprotein levels in SU-DHL-1 cells and the EML4-ALKprotein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM.
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