10-Deacetyl-7-xylosyl paclitaxel
Catalogue Number: S0563-SEL
| Manufacturer: | Selleck Chemicals |
| Type: | Biochemicals |
| Shipping Condition: | Blue Ice |
| Unit(s): | 25 mg, 5 mg |
Description
Description: 10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Badprotein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL, which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9.
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