Bosutinib
Catalogue Number: S1014-SEL
| Manufacturer: | Selleck Chemicals |
| Type: | Other Inhibitors |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 50 mg, 200 mg, 1 g, 10 mM (1ml in DMSO) |
Description
Description: Bosutinib is a novel, dual Src/Ablinhibitor with IC50of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERKand JAK/STAT3signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.
Additional Text
Caution
FOR RESEARCH USE ONLY
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