Bosutinib

Catalogue Number: S1014-SEL

Manufacturer:Selleck Chemicals
Shelf Life:24 months
Molecular Formula:C26H29Cl2N5O3
Type:Other Inhibitors
Alias:SKI-606
Shipping Condition:Blue Ice
Unit(s): 10 mg, 50 mg, 200 mg, 1 g

Additional Text

Caution

FOR RESEARCH USE ONLY

Smile String

CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC

Short Description

Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.

Storage Note

2 years -80 in solvent

Price
£120.00


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