Bosutinib
Catalogue Number: S1014-SEL
| Manufacturer: | Selleck Chemicals |
| Shelf Life: | 24 months |
| Molecular Formula: | C26H29Cl2N5O3 |
| Type: | Other Inhibitors |
| Alias: | SKI-606 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 50 mg, 200 mg, 1 g |
Additional Text
Caution
FOR RESEARCH USE ONLY
Smile String
CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Short Description
Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.
Storage Note
2 years -80 in solvent
Inhibitor Handling Instructions
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