Crizotinib
Catalogue Number: S1068-SEL
| Manufacturer: | Selleck Chemicals |
| Shelf Life: | 24 months |
| Molecular Formula: | C21H22Cl2FN5O |
| Type: | Other Inhibitors |
| Alias: | PF-02341066 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 5 mg, 50 mg, 10 mM/ 1 mL, 200 mg, 1 g |
Additional Text
Caution
FOR RESEARCH USE ONLY
Short Description
Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.
Smile String
CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Storage Note
2 years -80 in solvent
Inhibitor Handling Instructions
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