Crizotinib

Catalogue Number: S1068-SEL

Manufacturer:Selleck Chemicals
Shelf Life:24 months
Molecular Formula:C21H22Cl2FN5O
Type:Other Inhibitors
Alias:PF-02341066
Shipping Condition:Blue Ice
Unit(s): 5 mg, 50 mg, 10 mM/ 1 mL, 200 mg, 1 g

Additional Text

Caution

FOR RESEARCH USE ONLY

Short Description

Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.

Smile String

CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

Storage Note

2 years -80 in solvent

Price
£120.00


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