Catalogue Number: S1210-SEL
Manufacturer: | Selleck Chemicals |
Shelf Life: | 36 months |
Molecular Formula: | C20H22N8O5 |
Type: | Other Inhibitors |
Alias: | NCI-C04671, Amethopterin, CL14377, WR19039 |
Shipping Condition: | Blue Ice |
Unit(s): | 100 mg, 500 mg, 10 mM/ 1 mL, 1 g |
FOR RESEARCH USE ONLY
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.
3 years -20°C(in the dark) powder1 year -80°C(in the dark) in solvent