Catalogue Number: S2853-SEL
Manufacturer: | Selleck Chemicals |
Type: | Other Inhibitors |
Shipping Condition: | Blue Ice |
Unit(s): | 5 mg, 50 mg, 10 mM/ 1 mL, 200 mg, 1 g |
Description: Carfilzomib (PR-171) is an irreversible proteasomeinhibitor with IC50of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagyand induces cell apoptosis.
FOR RESEARCH USE ONLY