Catalogue Number: S8279-SEL
Manufacturer: | Selleck Chemicals |
Type: | Other Inhibitors |
Shipping Condition: | Blue Ice |
Unit(s): | 100 mg, 20 mg, 10 mM/1 ml, 1 g |
Description: Shikonin, a potent and specific Pyruvate kinase M2 (PKM2)inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channelactivity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α)and prevents activation of nuclear factor-κB (NF-κB)pathway via proteasomeinhibition.