Catalogue Number: BS-2162R-BSS
Manufacturer: | Bioss Inc |
Shelf Life: | 12 months |
Type: | Polyclonal Primary Antibody - Unconjugated |
Alias: | SK; DKK-1; Dickkopf-related protein 1; Dickkopf-1; hDkk-1; DKK1; UNQ492/PRO18 |
Shipping Condition: | Blue Ice |
Unit(s): | 100 ul, 20 ul |
Host name: | Rabbit |
Clone: | |
Isotype: | IgG |
Immunogen: | KLH conjugated synthetic peptide derived from human DKK1 |
Application: | ELISA, ICC, IF, IHC-P, WB, IHC-Fr |
Description: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
DKK1
22943
O94907
Protein A purified
1 ug/ul
Polyclonal
Unmodified
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.