ATG4D Polyclonal Antibody

Catalogue Number: BS-4009R-BSS

Manufacturer:	Bioss Inc
Shelf Life:	12 months
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	APG4D; AUTL4; APG4-D; Cysteine protease ATG4D; AUT-like 4 cysteine endopeptidase; Autophagin-4; Autophagy-related cysteine endopeptidase 4; Autophagy-related protein 4 homolog D; ATG4D
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	KLH conjugated synthetic peptide derived from human ATG4D
Application:	ELISA, ICC, IF, IHC-P, WB, IHC-Fr

Overview
Datasheets

Description

Description: Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.

Additional Text

Gene Name

ATG4D

Gene ID

84971

Uniprot ID

Q86TL0

Purification

Protein A purified

Concentration

1 ug/ul

Antibody Clonality

Polyclonal

Modification

Unmodified

Storage Note

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

bs-4009R Datasheet

Price

£313.00

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