Challenges When Treating IBD with Biologics

Monoclonal antibody (mAbs) biologics have been used to treat inflammatory bowel disease (IBD) for 20 years¹. Despite the successful use of biologics as therapies for Crohn’s disease (CD) and ulcerative colitis (UC), these diseases remain difficult to manage. As a result, patients and healthcare providers are met with many challenges when treating IBD with biologics such as variable drug response, immunogenicity, subtherapeutic levels, and the overall cost for IBD patients^2,3.

Variable Drug Responses to Biologics

Research demonstrates that various responses to the primary biologic can occur when treating IBD. Only an estimated 45% of Crohn’s disease cases treated with TNF-alpha blockers reach clinical response². Studies also indicate that 50-70% of all CD patients do not achieve complete remission after 6 months of treatment with TNF-alpha blockers^4,5. Furthermore, 20% of CD patients treated with TNF-alpha blockers do not respond clinically to their primary biologic which is now referred to as primary non-response (PNR)². Additionally, research demonstrates that an estimated 35% experience a loss of response (LOR) as biologics treatment progresses².

PNR and LOR have proven to be difficult challenges for IBD patients and healthcare providers to overcome. Further research investigating drug responses to biologics is necessary to help improve IBD care. Studies indicate that several factors are associated with primary non-response and loss of response in IBD cases treated with biologics including immunogenicity and subtherapeutic levels of the biologic⁶.

Immunogenicity of Biologics

Research shows that when a biologic is taken, there is a possibility that the body may mount an immune response against the drug which can involve the formation of anti-drug antibodies (ADAs). This occurrence is known as immunogenicity and can affect both the pharmacokinetic (PK) and pharmacodynamic (PD) properties of biologics⁶. The development of ADAs may cause adverse events, PNR, LOR, and in rare extreme cases, lead to toxicity⁶. Many factors such as the design of the biologic, dosage size and administration method, immune system status, and genetics can affect the immunogenicity of biologics⁶.

Discovery of Biologics Immunogenicity

The immunogenicity of biologics was first identified in patients treated with infliximab, and prompted the development of other TNF-alpha blockers such as adalimumab^7-9. However, at week 4 of a pivotal adalimumab clinical trial, only 21% of patients who had previously been treated with another TNF-alpha blocker (infliximab) achieved remission¹⁰.

These findings suggest that a proportion of patients can develop resistance to multiple biologics rather than to one single agent¹⁰. The identification of immunogenicity reactions caused by both infliximab and adalimumab influenced the development of new classes of biologics to treat IBD¹¹.

Subtherapeutic Levels of Biologics

In 2003, findings from a key study revealed a positive correlation between infliximab concentrations and the duration of response, therefore demonstrating the importance of maintaining optimal infliximab concentrations⁷. Anti-drug antibody:drug immune complexes may increase the clearance rate of biologics and lead to subtherapeutic levels and loss in efficacy⁶. However, research also indicates that subtherapeutic levels of biologics with or without the formation of ADAs can lead to LOR and further complicate IBD treatment⁷. Studies have shown that increasing the dose of infliximab in IBD cases with subtherapeutic levels can lead to improved clinical response¹².

In order to improve care, though, more research exploring the relationship between pharmacokinetics and efficacy of biologics in IBD cases is still needed^13-15.

Cost of IBD Biologics

Research indicates that the annual health care cost per member and the usage of biologics for treating IBD is increasing¹⁶. Between 2011 and 2013, annual health plans in the U.S. paid an estimated $20,000 USD in IBD care costs per member¹⁷. One third of the annual cost for this time was attributed to TNF-alpha blocker biologics alone. Furthermore, healthcare plans during this period paid more as age and the number of comorbidities increased¹⁷. Another study reported that the annual cost of IBD treatment rose to $36,051 USD per member in 2015¹⁶.

Investigations also suggest that healthcare providers optimize biologics therapy use in order to reduce the burden of IBD¹⁷ . However, due to the immunogenicity of biologics, it has been difficult to develop methods to optimize IBD therapies¹⁴.

Overcoming Challenges When Treating IBD with Biologics

Although the advent of biologics revolutionized the standard of care for inflammatory bowel diseases, there are still many challenges when treating IBD with biologics^2,3. More research on the immunogenicity of biologics can potentially reduce loss of response and prevent primary loss of response to those therapies². Methods to optimize IBD biologics treatments may reduce the occurrence of subtherapeutic levels, and also increase clinical response^2,3. A deeper understanding of both immunogenicity and optimal biologics concentration can lead to reduced treatment costs and improve the quality of life for IBD patients around the globe.

References

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