Equipment

Compact System for Molecular Pathology

The TintoDetector ImmunoDNA System allows users to perform Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF) and In-situ Hybridization (ISH) in one easy to use open platform.

TintoDetector ImmunoDNA System Overviews and Features

The Bio SB TintoDetector ImmunoDNA System is a compact molecular pathology system which allows for the full implementation of immunohistochemical (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF) and in-situ hybridization (ISH) protocols. Ideal for use in diagnostic or research laboratories looking for a cost-effective, semi-automated and open platform.

The Bio SB TintoDetector ImmunoDNA System consists of a durable stainless steel housing, eight solution dishes, incubator unit (for reagent incubation, nucleic acid denaturation, probe hybridization and stringency washes), and 30-well reagent holders. With a compact footprint, ease of use and versatility, the TintoDetector offers flexible protocol implementation at a competitive price.

• Eight staining dishes for reagents and buffers.
• Built in incubator for ISH protocols that reaches 110 degrees celsius, stores 3 incubator presets.
• Stainless steel construction that is chromogen and xylene resistant.
• Small bench footprint with low power requirements.
• Supports ICC, IHC, CISH, and FISH protocols. Open system

TintoDetector Lab Applications

TintoDetector Components

TintoDetector Wash Procedure

Step 1 – Load Slides

Load slides in TintoDetector Holder, face to face and properly ordered.

Step 2 – Apply Reagents to Reagent Holder

Apply reagent to TintoDetector 30-well Reagent Holder. Each reagent well can hold about 200 μl of reagent.

Step 3 – Draw Reagents into Slides

Place TintoDetector slide holder over 30-well reagent holder, ensuring that reagents line up with slides. Press slide holder gently against reagent holder. Capillary gap action will draw reagent. Transfer TintoDetector Slide Holder to Incubator.

Step 4 – Incubate

Incubate Slide Holder using the TintoDetector Incubator.

Step 5 – Rinse

After the reagent incubation, eliminate the used reagent into an absorbent pad by gently pressing the slides on the absorbent pad to drain the liquid. Draw washing buffer into the capillary space and repeat the washing process 3 to 5 times. After washing proceed to draw the next step reagent before another incubation.

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Compact System for Immunocytochemistry, Immunofluorescence and Immunohistochemistry

Perform Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF) and In-situ Hybridization (ISH) in one easy to use open platform.

A demonstration of the Fast Mohs technique on our Bio SB TintoDetector ImmunoDNA manual staining system.
Featuring our selection of TintoFast antibodies, and detection systems for fast IHC cancer detection after Mohs surgery.

Overviews and Features

The Bio SB TintoDetector Mini Immuno System is a capillary gap based system which allows for full implementation of Immunocytochemistry (ICC), Immunofluorescence (IF) and Immunohistochemistry (IHC) protocols in your diagnostic laboratory. The Bio SB TintoDetector Mini is intended for laboratories which require flexibility in their diagnostic needs, yet may not require high volume slide output offered by larger systems, such as the full-size Bio SB TintoDetector or the automated Bio SB TintoStainer.

The Bio SB TintoDetector Mini Immuno System is an open system that allows for the use of any detection system or reagent. The TintoDetector Mini paired with accessories, like the Bio SB TintoRetriever Pressure Cooker, allows laboratories to implement a wide variety of lab protocols at a low cost.

• Four Staining Dishes for reagents and buffers.
• Five 30-Well Reagent Holders
• Stainless steel construction that is chromogen and xylene resistant.
• Small bench footprint.
• Supports ICC, IHC, and IF protocols. Open system.

TintoDetector Mini Wash Procedure

Step 1 – Load Slides

Load slides in TintoDetector Holder, face to face and properly ordered.

Step 2 – Apply Reagents to Reagent Holder

Apply reagent to TintoDetector 30-well Reagent Holder. Each reagent well can hold about 200 μl of reagent.

Step 3 – Draw Reagents into Slides

Place TintoDetector slide holder over 30-well reagent holder, ensuring that reagents line up with slides. Press slide holder gently against reagent holder. Capillary gap action will draw reagent. Transfer TintoDetector Slide Holder to Incubator.

Step 4 – Incubate

Incubate Slide Holder using an empty staining dish.

Step 5 – Rinse

After the reagent incubation, eliminate the used reagent into an absorbent pad by gently pressing the slides on the absorbent pad to drain the liquid. Draw washing buffer into the capillary space and repeat the washing process 3 to 5 times. After washing proceed to draw the next step reagent before another incubation.

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Hydrophilic Plus Slides

TintoDetector Cap Gap Plus Slides

• The Hydrophilic Plus microscope slides are novel positively-charged slides for IHC, ICC, FISH and CISH with significantly improved tissue-adhesion characteristics compared to other commercially available slides.
• The Hydrophilic Plus microscope slides are superior in their ability to retain tissues that otherwise tend to detach from slides after thermal epitope retrieval procedures (HIER).
• The Hydrophilic Plus microscope slides carry approximately three-times the number of positive charges compared to other commercially available slides.
• Unlike other commercially available positively-charged slides, which all have hydrophobic working surfaces, the Hydrophilic Plus slides are strongly hydrophilic. The Hydrophilic surface reduces tissue wrinkling during mounting and facilitates water-based reagent application, which may improve staining and produce less background.

Characteristics of the Hydrophilic Slides

• The Hydrophilic Plus glass slides are strongly hydrophilic.
• The Hydrophilic Plus glass slides carry approximately three times the number of positive charges compared to commercial positively-charged slides.
• All commercially available positively-charged microscope slides were found to be hydrophobic.
• The Hydrophilic Plus glass slides display improved tissue-adhesion characteristics compared to other commercially available slides.