New study shows that ICH1132 is an established alternative to BE0146 for tumor growth inhibition studies, showcasing significant early- stage efficacy and a consistent performance profile.
ICH1132 is ichorbio’s low endotoxin rat anti mouse PD-1 antibody, clone RMP1-14. BE0146 is the same antibody from Bio X Cell which is currently the gold standard RMP1-14 clone.
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Early-Stage Efficacy | Significant tumor growth inhibition observed on days 14, 17, and 19 in our recent study. |
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Consistent Performance | Trend towards higher tumor growth inhibition percentages compared to BE0146. |
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Lower Endotoxin Levels | ICH1132 (0.013 EU/mg) vs BE0146 (0.056 EU/mg), potentially beneficial for certain research contexts. |
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Similar Safety Profile | Comparable effects on body weight to BE0146, indicating similar tolerability. |
This graph illustrates the change in tumor volume over time for three groups: the control group (Isotype Control), and two treatment groups (ICH1132 and BE0146). The y-axis shows the tumor volume in cubic millimeters (mm³), while the x-axis represents the number of days since treatment began. Error bars indicate the standard error of the mean (SEM) for each data point.
This graph illustrates the Tumor Growth Inhibition (TGI) percentage for ICH1132 and BE0146 over the course of the study. The y-axis represents the TGI percentage, where higher values indicate greater tumor growth inhibition relative to the control group. The x-axis shows the number of days since treatment began.
Potential for clearer results in early-stage tumor growth studies
Opportunity to explore the impact of lower endotoxin levels
Supports the 3Rs principle in animal research
Viable alternative to BE0146
“Our comparative study has shown some interesting trends for ICH1132, particularly in the early stages of tumor growth inhibition. While the differences weren’t maintained throughout the entire study period, the consistent trend towards slightly higher efficacy is noteworthy. We’re interested in seeing how ICH1132 performs across different research settings and how it might contribute to more refined experimental protocols.”
Dr. Elaine Zhang, Lead Researcher
ichorbio’s RMP1-14 antibody is 75% less than Bio X Cell on average, with a maximum difference of 101%.
This data is correct as of 9th January 2024. The data shown below is the standard prices listed on the Bio X Cell website and does not include any special offers they may provide from time to time.
| Size | ichorbio’s RMP1-14 Antibody | Bio X Cell’s RMP1-14 Antibody | % difference |
| 5mg | $250 | $411.45 | 65% |
| 25mg | $700 | $1405.30 | 101% |
| 50mg | $1200 | $2702.20 | 73% |
| 100mg | $1800 | $2895.75 | 61% |
ichorbio’s RMP1-14 can be only a third of the price for the same size vial from Bio X Cell for industry customers.
This data is correct as of 9th January 2024. The data shown below is the standard prices listed on the Bio X Cell website and does not include any special offers they may provide from time to time. ichorbio has the same pricing for our academic customers as for our industry customers, whereas Bio X Cell charges a premium to their industry customers.
| Size | ichorbio’s RMP1-14 Antibody | Bio X Cell’s RMP1-14 Antibody | % difference |
| 5mg | $250 | $633 | 153% |
| 25mg | $700 | $2162 | 209% |
| 50mg | $1200 | $3188 | 166% |
| 100mg | $1800 | $4455 | 148% |
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